State of spatial memory and antioxidant system activity of rats in the dynamics of development of blast-induced traumatic brain injury

The main purpose of this study was to investigate the changes in spatial memory and catalase activity dynamics blast-induced traumatic brain injury (bTBI). experiment carried out on 67 albino male Wistar rats, which were randomly divided into three groups: I group – experimental (n=34), animals subjected inhalation anesthesia with halothane, fixed simulated by generating a shock wave an overpressure 26.4±3.6 kPa, II sham only fixation III intact (n=34). After behavior, euthanasia performed, blood taken shelter. Histopathological examination showed disturbances both hippocampal neurons microcirculature. In post-traumatic period mild bTBI there observed significant (p<0.01) impairment rats group, established as prolongation latent time search Barnes maze: 39% day 1, 76% 3, 65% 7 61% 14 study. analysis revealed decrease enzyme plasma comparison 1 35% (p<0.01), 3 27% 12% (p<0.05), indicates involvement reaction hydrogen peroxide inactivation. Correlation between negative relationship medium degree (r=-0.3, p<0.01) (r=-0.2, weak period, indicating increased formation free radicals during period. One-way variance (H1, effect rat state maze days It that oxidative stress is important link pathogenesis disorders first week